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Sedating anti histamine

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Just wondering if someone could supply some binding affinity charts to this thread. Histamine antagonism in the brain is inherently sedating, but apparently many of the 2nd-gen antihistamines are poor at crossing the blood brain barrier, and therefore less sedating, (it depends on which one though, some 2nd-gen ones are still sedating).

Adrenergic antagonism helps with sedation/anxiolysis too. A few antihistamines can have additional mechanisms of action that may add to anxiolysis/relaxation/sedation.

For example, when you're fighting a cold (the rhinovirus), histamines widen the blood vessels in your nasal cavity, causing nasal congestion.

Additionally, the increased fluid leakage from your blood vessels, combined with an increased mucous production — also caused by histamines — can result in a runny nose.

It's stored in cells called mast cells, in almost all tissues of the body, and is released when the body reacts to a foreign substance (known as an allergen).

Some common kinds you can buy over the counter include: Note: Some antihistamines are mixed with other medicines.

These could include pain relievers or decongestants.

They also make blood vessels more permeable, allowing proteins and white blood cells to seep into the damaged or infected tissue.

But there are side effects to this healing process.